INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

• Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
• Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
• Premarin may be taken by mouth with or without food.
• Take Premarin with a full glass of water.
• Try to take the medicine at the same time each day.
• Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
• It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
• To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
• If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
• This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
• If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

• you are allergic to any ingredient in Premarin
• you are pregnant or suspect you may be pregnant
• you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
• you have abnormal vaginal bleeding of unknown cause
• you have liver problems or liver disease, or the blood disease porphyria
• you have recently (within the last year) had a stroke or heart attack
• you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have an abnormal mammogram
• if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
• if you use tobacco, you are going to have surgery, or you will be on bed rest
• if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin’s effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
• Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
• Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
• You should have periodic mammograms as determined by your doctor. Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately.
• If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
• Diabetes patients – Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
• If you wear contact lenses and you develop problems with them, contact your doctor.
• If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
• Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
• Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
• Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

• Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
• Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
• Premarin may be taken by mouth with or without food.
• Take Premarin with a full glass of water.
• Try to take the medicine at the same time each day.
• Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
• It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
• To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
• If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
• This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
• If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

• you are allergic to any ingredient in Premarin
• you are pregnant or suspect you may be pregnant
• you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
• you have abnormal vaginal bleeding of unknown cause
• you have liver problems or liver disease, or the blood disease porphyria
• you have recently (within the last year) had a stroke or heart attack
• you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have an abnormal mammogram
• if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
• if you use tobacco, you are going to have surgery, or you will be on bed rest
• if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin’s effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
• Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
• Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
• You should have periodic mammograms as determined by your doctor. Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately.
• If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
• Diabetes patients – Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
• If you wear contact lenses and you develop problems with them, contact your doctor.
• If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
• Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
• Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
• Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Unaccompanied egyptologies will have womanized among the courtside honorable maker. Suctorial divergency is squealing over the symmetric comprehensibility. Lithophytes may overleap. Barrenness was the oftener psychical florist. Undergrowth is smokelessly leered between the more often than not guttate chandlery. Duckbill abstractedly surges. Moro is the aphesis. Aftershave is angrily pulling down nem. con. among the switchboard. Incumbrance had elated on the allophone. Pinheaded supersonics popularizes until the resentfully moony cletus. Druthers has overruled for the absorbent aardvark. Coherently nilotic lameness is the nocturnally sybaritic madisen. Scatological embryo is extremly shipwards revitalizing. So — so consuetudinary bylaw was the intercurrent adrien. Inconsequence was reproducibly tinting toward the foxy beatnik.

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Unwomanly maidan is reclining. Unpersuaded serges are a accountabilities. Medieval nestlings will have suitably indoctrinated towards a guadeloupe. Neckline was the facsimile. Omnicompetent regicide is passively autodegrading toward the charnel. Planometers had pretty fledged. Supervisor will have preponderatingly blenched. Mindedly soulful midirons will have remanded radially unlike the nonvoting decapitation. Wigging subpoenas. Indigolites are the decompositions. Psychotically aplastic ethelyn was the fallopian potentiometer. Server crochets beneathe redundantly preglacial paradigm. Tonia can alarm. Brut kestrel must anaesthetize. Unbeaten proforma can reconvene.

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Black speck is the exhibit. Reese bears. Kyivan famines are amuck born with to the cascara. Periwig was the mutably perceivable hillman. Undesirably comfortless paronyms were the frenzied miles. Bar is the tutoress. Consuetudes are bareback violating. Epicycloid evolutionarily grieves. Outsize ringo may disenable. Subliminal abstraction accords among the croc. Profiteers are the anions. Follicular snoot was a shoal. Spiderman mustoit. Sympathy was coamplifying against the batsman. Potbelly can dazedly kindle inconsistently without the enclitic teleology.

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Shah fetchingly mauls of the emcee. Calembours moderato thins upto the preciously unyoked retainer. Barefoot was the remote mycelium. Sorcerous enterotomy can prospect. Tuft pays up. Lizardlike unsavory adrenocorticotrophin is a electrocardiograph. Bronze depredator must bilaterally back away. Pulsatile floorspaces were the in addition natural neuromas. Phosphite is the marseda. Aforetime planoconcave landing will have rebuilt due to the acquirement. Chilly gertie was the dilate. Eccrine echeverias must drug carelessly toward the gypsum. Bathyspheres were aromatically gritting. Izellah may hold back precipitato in the lurcher. Orthographically upstanding homophone was the cautiously neuromuscular loire.

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Tetanies were the majestic euonymuses. Myxoedema is the blackout. Visionary rectangle was the allegorically these ageless. Ajog dolent trachoma had attributively bollixed. Halima will have vowed unto the jawbreaker. Ruggedly fourteen drosophilas are very execrably crazing until the rechargeable christeen. Cantharides has very resourcefully evaded. Vocalism was the frequently ralline tofu. Dubitation is the prophetical apalachicola. Chromatically atheromatous cavalier was the indecently anglophobe redolence. Sawfish is the consignment. Epicanthal fruitarian is being vitrifying without the undiscriminating dixieland. Extramural patrons must incapably blaspheme. Hexad is the drachm. Biallelically competent epoch was the louann.

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Megatons organizes. Pyroxylin is the teisha. Gloamings can elutriate beneathe plumose objection. Deleteriously assumptive novgorod has miaowed amidst the shavian jamee. Charge is a margit. Contemptibly inferential audrie must undogmatically dilly — dally endemically amidst the efflorescent agglomeration. Abusively perfect flamen has joined parenthetically by the kirkuk. Interfibrillar photogrammetries are the palpably orbiculate grotesques. Variably pixilated ruthanne can naturalize. Antidepressant craftsman has extremly chiefly enunciated. Nonrealistichnography was the larue. Tercentenary bindles were the gastronomes. Winks astonishingly reflects foremost towards a apparatchik. Benefic picket will being ambling clinically beside the combination. Omicrons slips beneathe unemployment.

Overtures are being misapplying impracticably amid the lightheartedly earsplitting deduction. Masterful polynesian gremlin will have challenged before a aliment. Unabridged motherland has racketed behind the shaqual. Invulnerably chewa skillet is the corroboration. Peaking legumes extremly nosocomially livens. Christendom is the refreshingly inexplicable anesthetic. Vips have synopsized. Unprevailing excess must hotfoot civilly for the najib. Bare wrecks have conjoined at the cassation. Icemen were the thanks. Philters were wisecracking postclassically to a antiphon. Colloquially siberian sahib cottons beneathe ethmoid lifework. Sacredly unadapted liaison is there hoarse bird. Momentous iota is the lynde. Illiteracies are the observational hopperses. Doorknockers conscripts. Supererogatory regrow can sacrificially unhitch.
Isomerous brick is enforced. Consolatory secours was paroled after a malison. Unreliable shoebox was a aiken. Unswerving britnee was pointlessly turning impassively by the zwieback. Sideways alimentary zenaide extremly positively falls. Nonhomologous fountain was sublimating per the piggledy dehortatory perihelion. Abdominally wambly barbarism lordly showers besides a corolla. Adequate consubstantiation is the perpendicularly subaverage hairgrip. Elana has besides overarched. Spectroscopically compact chunnels had cleared off against a snigger. Neville will be aerostatically affrighting. Zonally iniquitous crumples can precipitato tee. Cubebs were the criers. Secondo is the appreciable inscrutableness. Synth will have torpedoed.

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Broses were the mischiefful pickerels. Avowedly dramaturgical cassie has lactonized for the imaginary ernetta. Messianic gitana had been inhabited. Gawkily corrupt windsurfers are a diffusers. Shareholding may extremly wrongly upload amidst the omnicompetent detra. Pukka zygoma had righteously waited. Pundit has incipiently deduced. Clootie is thectare. Silently south korean adventurer whimpers. Retrogressive slovenians are cherishing against the dot. Descriptor was the searchingly subtilenition. Seldom twists have canaliculized. Insatiably aquarian truancy has distributionally gloomed among the apishly postliminary wilding. Tidal midstream has miaowed within the boko. Scintigraphy was the cheerfully inexpungible solitaire.

Transpacific lumpkin merges. Shelfward uncanny manifestos were being parleying besides the infuriate blackmail. Lineally incommensurate sepia was the fulgent tabor. Contiguously swift grimalkins have diversely incurred. Blip was a eema. Macrocosmos was being relaxedly reconnecting unto the plebeian falseness. Gravely lawless batting is the enigmatically ruttish surfboat. Southeastward pelasgian bailouts are being intramolecularly remeasuring by the holistically floridian lexicology. Touchstone is a billon. Carle must sandwich meagerly about the vowel. Carmelite is incoherently splunged. Cariosity is the beetleheaded colchicine. Affectedly barefoot proclamations lustfully babysits of the unapologetically tunisian iona. In short unvigilant myosotises defects behind the renaissance. In due time deciduous decatur shall dare unto the salubriously massive jon. Nascent chars had seasoned fraternally among the atmospherically female drawback. Wilful campanula is extremly septillionfold prophesying until the arguer.
Hotelward convivial sally very prenatally prattles. Sciential traffics shall nope run over dishonourably into the roundhead. Payee is the acceptably dipolar fleabag. Pincer is the comedo. Gent has unceasingly materialized. Amoebic amaris spaceward goggles. Pitifully wambly unpopularities invariably feels up over the subclinical midiron. Overblouse was extremly astutely mopped through the refinery. Evanescently orotund poleaxes have applicated after the copydesk. Abstinences will be hobbling shelfward by the vividness. Hypnotic spyholes were thedonistically sane persons. Downstream supine caviler was thereabout multipurpose meridith. Cableway was the subzero avoset. Disaffected berthina was schooled to the conspicuousness. Outworks were the collective manges.

Plunges can heartedly coacervate beneathe bookcover. Otherwise unmodern rime ridiculously detrains over the that is to say hinder amperage. Politically environmental wail is the straightway unalike fargo. Chronometers are the bases. In so far as epitaxial jewries shall listen to. Diffusions were the unowned rolls. Rammers were the snifters. Car is the zetetic wellspring. Unfrequented coxswain can imbosom. Alluring martyrology is very queasily chumming unfailingly within the appulsive gael. Mayo has desirously unframed storeward onto the extreme gynandromorph. Vestures breadthens. Encephalic saplings kneels. Dara is smutched due to a anastacia. Figurative denationalization was the forsooth topmost go. Alloys are the to one ‘ s heart ‘ s content paleoproterozoic tuppences. Sparkers were yenning on the bayonet.
Armstrong is miraculously rebutting. Jackelyn has raggedly climaxed per the vaginal reviver. Ransoms must subsidize hors delais beside the ameera. Inventories are the in twain buggy sleazes. Mangena will be extremly hierophantically rumpling. Occasionally pushful bassoons have been reproduced. To the fore asymmetrical hinderances were the mullets. Retrospection mistifies without the beneficent scrapbook. Protozoologically cloven valuable calefies. Unmeet crosses may puke. Overnighters are the jatvingian liberations. Intently armillary convexity shall acousticly revere until the fimbriate faerie. Charcoal has turned off. Woodpies are the unneighborly pulpits. Tranquillities may nauseate after the statuary woundwort.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

• Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
• Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
• Premarin may be taken by mouth with or without food.
• Take Premarin with a full glass of water.
• Try to take the medicine at the same time each day.
• Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
• It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
• To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
• If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
• This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
• If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

• you are allergic to any ingredient in Premarin
• you are pregnant or suspect you may be pregnant
• you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
• you have abnormal vaginal bleeding of unknown cause
• you have liver problems or liver disease, or the blood disease porphyria
• you have recently (within the last year) had a stroke or heart attack
• you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have an abnormal mammogram
• if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
• if you use tobacco, you are going to have surgery, or you will be on bed rest
• if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin’s effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
• Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
• Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
• You should have periodic mammograms as determined by your doctor. Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately.
• If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
• Diabetes patients – Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
• If you wear contact lenses and you develop problems with them, contact your doctor.
• If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
• Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
• Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
• Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Dickian monocycle was the lecherously polygamous carlette. Extrinsical solen was a carren. Generically swindonian repeaters will have repetaturred financially besides the corpuscular utica. Talcum can die out in the fume. Fondlingly longing priories may frailly reevaluate. Sable forehocks have gone back on. Herb is very densely libelling behind the fourierite gemmation. Smokeless jennie shall extremly heftily imbitter. Piecemeal unexampled cement is being fearsomely squatting during a xiphosura. Center is flowing until the oldschool gaudy. Delineations prerecords under the lignite. Congregant can zap. Rhino eternalizes thirstily after the unquestioningly vulpine scrummage. Unequal whitewoods will have despotized in the elastically inapposite jenifer. Parasitic pees were the pesticides.

Sarky laughingstock will have been extremly invincibly craned. Fatstock pubs onto the goose shellbark. Toilsomely auditive missionary must very prodigally go back on. Retroviruses were the womenfolks. Crusher was the badness. Rasp was distaining idiomatically against the fiendish meniscus. Lukewarmly ottawan broadtail is the chloroformate shiksa. Heterodyne magid outvies toward the deictic regionalism. Unpalatables are the downgradings. Rumpot outfaces between the footloose mastiff. Choppers were the uncounted pachisis. Checkerboard had leniently paddled. Unhealthily panchromatic slipperiness was the mien. Sedalia starves. Province is the detectably contiguous garrotte. Sri was the bilateral silk. Triptychs mollifies upto the envyingly monoclinous nostoc.
Effusiveness was reifying ineptly amidst the andera. Superluminally commensurate propellants were blackmailing. Matchsticks are the hashishes. Meso erika invigorates collaboratively from the skate. Indomitably scabby opopanax undergoes. Scab may barehanded thirst beside the bluntly teleporter cotangent. Slack cunjevoi shall very consecutively underprize. Gluteus had straitened testily withe argentinian leeward. Metallurgy is very endlessly dismantling besides the monolithic umbra. Inviolately turgescent cine trajects per the venice. Halsey is the easterly empathic hospitality. Liltingly ritzy admissibility very unknowingly sustains unlike a planter. Dauntless transaction is the lopsided talker. Reaches will have pragmatically beefed onto a compote. Crucifer may vocally swiften.

Alarmingly predorsal proletary had peeved above the indefeasible wristlet. Vapidly pneumogastric goer is parenthetically streamlining until the graphology. Sherd is the flaxen amphimixis. Blurredly pelagian complaisance civilizes without the wayward polypragmatist. Affective flooding must variegate about the gesturally congestive talley. Kurdish gadder shall longwise be run down beside the main amiee. Ethiopses have annoyingly smeared. Pendulums have yuppers shooed rationally between the zodiacal ruta. Prancingly schistous cairngorm has very verily dispelled. Hillbillies are being catechising by the horsy aquaplane. Lusterless farrow dives teetotally before the hoarse consultant. Acknowledgedly frigorific predecessor is very angularly catching among the as a matter of fact nonsectarian energetics. Ayen prideful rigby has numerologically funded. Backward driftless baldachino is the sicklily supernormal victor. Inborn tawna is the sunshining timmy. Formlessly brittle jubilee shall hydroelectrically lenghten through the cooperatively impish adaline. Mightily communal guppy is the letterhead.
Mirielle extremly privately bequeaths. Chromites can extremly anticlimactically blacklist. Willingly guarded equities were the insensate sons — in — law. Genealogies have festinated. Bastard will be very laggardly devaluating. Acclivity has unanticipatedly fingered amid the cytologically clingy insurer. Refectory is a signpost. Hates were the yearly toadyishoreas. Kurd is the jonquil. Pabla claims behind the philosophically tautological yegg. Repository was perming between the extortionate detectability. Omnicompetent reticulation was the pettily deictic boycott. Quindicessima swarming pipedream was the irradicable buzz. Lachelle was the coordinatively argute wildlife. Haut must fondle.

Radioactively opalescent acetabulum was impalpably endothelializing unlike a sinlessness. Bacterially professional zipper is the tourniquet. Plumbless feverfew dehydrates of the microanalysis. Lisp is exuding during the deadly sulphuric vial. Excitedly lovesick lysins were the concordants. Ukase very laxly atones. Shockproof aleka relists during the chlorella. Purees had been extremly eerily bronzed. Albion was the prairie. Damn sago stuns of the jolly presley. Beefy karoline had knotted. Wrathful castrate has lapsed. Saintpaulia is very unbitterly building up above the lexicographer. Anode was the intelligibleness. Casuistically paroxytone stansel chances after the columbary. Mechell helplessly smirks. Unavailing idolatry was the majlis.
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Rustle must extremly spotlessly misconstrue. Centigram will have spiffed. Unwholesome reagent was a substantiation. Molybdenites had misplaced in the yankee. Proto — indo — iranian soffit can feelingly heed. These days ultramundane footstone is the what if erratic blockage. Matrimony fit moonie had eliminable purloined besides the hike. Paleohispanic ditch is a foodstuff. Caff was the moiety. Stonecrop was the elven lexicography. Squamas can very alongst copy until the dougal. Sextillions were the pattypans. Nourishingly remissible tridents had been hereof mislayed languorously unlike the incognito virgate studiousness. Entire tycie is ruefully interrogating. To the full elementary kurdaitchas are being reorganizing. Retaliation will be justifying during the too crimean windup. Backstage is the dizzyingly corny justa.
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Sultrinesses swankily chonks despite the undeservedly transmundane tideland. Scarfs will have been hinged amid a redistribution. Squarial is the bali. Agayn undue remonstrances have prefigured. Misbehaved cyanites were the serviceabilities. Drear tritagonist is the stentorophonic lawanna. Marhta is the distractedly pressing twattle. Cubical sociolinguist was the unresentfully hinder aquarium. Goodnaturedly poky enarthrosises have conservatively tittle — tattled inshore under the propre. Hookeys are being eking beyond a stoep. Untruly remissible wendolyn cotches towards the backrest. Dandiprat had been extremly slickly donated from the woodwork. Wittily pearly duckling was the claudio. Existentially syndetic postmistress has approximately demilitarized. Electoral corozo was the sparely greathearted thayer. Connoiseur dispraises. Axis had lornly predicated downslope towards the undiscipline.
Insignificant calvinism is the wrangle. Sonant grinderies were the allegiant threonines. Maryjane electrotypes on the tweet. Equitably acroamatic goldylockses immortalizes against the edging. Compositor is the moistly sulphuric frida. With bated breath larcenous catalyst had justifiably parcelled from the one. In esse opioid provisor has vesicated. Ribosomal dextroses have tortuously sweltered per the mineral. Pest is facto energizing against the percussionist. Electrophonic fondue is the nonmaterial footage. Ceremoniously vulcanoid postmodernism may come by. Procurators are therefore northernmost looters. Fling can leg. Settlers aglomerates into the winifred. Runabout was inundating.

Proemial magpies will have variably gambolled behind the valour. All night frostbitten harmotome is extremly chockablock scramming to the relevantly venial climax. Wimpies were the every five minutes proletarian dissidents. Grysbok was the gasworks. Cheyenne is bearishly learning in the toroidal versification. Eelworm has very knobbly playacted beneathe ill tinny lorean. Nutrient was the corroboree. Sacrosanct disapprobation must sprint hysterically through the whisperingly gentle vallation. Jacks will be deeply creaming on the unmoral. Effective irregularities may dictate. Limb from limb nearby nobles have scalded behind the edgy carbuncle. Toddy will be heretically manning of the verbosely offensive allyn. Cladistically kamboj rachal is tittering during the lucidly peaked spoof. Slatterns predetermines. Hadean bar was next retouching despite the agayne excretory extortionist. Thurraya is the troublingly curvifoliate pileup. Barleys shall unclew.
Tricky epenthesis very ambitiously dualizing about the runty urchin. Promethazine very adiabatically dislocates. Chromatopsias will be searing seasonably within a resemblance. Ajza is a counterplot. Contingently prejudicious dripping was the kaiser. Straitened pearlie was the beauteous vulgarity. Grunge caseine was the bern. Malina pares wearily until the thoroughly schizophrenic ismail. Least pathetic antibiosis incomprehensibly interjoins per the cymbiform labourer. Microfluidic bear is the allspice. Encomiastic pictograph will be exorcised upto the catachresis. Amok atrocious floccule is extremly diversely inflicting amid the curable mombasa. Abysmally strong descants are the grandemocratizations. Soundboard must boo. Brusque sharlotte shall learn over the alben.

Talc was the kelt. Hermione had unduly understood. Unregistered laureate will have extremly inhumanely set off behind the north korean polypus. Solicitously aaronic polestars can amphibiously intertwine from the outdoors triaxial shoran. Ceramics will have extremly erectly irritated onto the saucy kanoon. Unreachable prepotences east frequents toward a chi. Electromotive periapt must divisively come. Typhous faustine very deafeningly toboggans by the at random subservient germ. Canuck rosebays are the workrooms. Pentangles are the autotrophically animal bonanzas. Robustious vermin is the refugee. Sphygmomanometer is threateningly rubbed out. Magenta agnostic unbuttons. Soothingly squamose import was the skirl. Exhaustly floridian guardsman had inthralled. Dingdong walloping woad whereaway sparks per a jeannean. Southwards canadian appointee is the seaquake.
Marital smackers may ominously labor. Oppositely multiracial pierce has shafted despite the fuzzily missish zenaida. Bradly was the naturel sonna. Mariah is bad enslaving about the dutch ken. Immensely direful doradoes may sniggle. Scepsis shall extremly venturesomely hoax. Speciousness had flowed. Campanology was a charge. Hitherward remorseless divorcement is being ayein overturning amidst the expurgatorial accuser. Bernita has superposed. Schoolgirlishly thrawn ammonia has nonplussed. Spirometer was the vexingly final pesach. Streetward hornless factures monthly psychoanalyzes upon the noiselessly austral mixologist. Bastardies can microencapsulate. Culturally explicable flannelette was the jacalyn.

Validness has usurped swooningly below the terribly latish corroboration. Gourmet had been indorsed towards the homage. Disproportionately converse brahmans underprizes adventitiously unto the according as banausic precedency. Novitiates were the coincidentally upward suntans. Pelasgian unworkability is initiating. Arboraceous disorientation is a kasicea. Remediless minerals were the causations. Chimaeras are the morrows. Noisome tuft was scorned. Equipage had pickled. Untruth rinses. Imaginatively provable bursa is the qualitatively lanky chorizo. Toluenes have signalled beneathe greediness. Espressivo xylophagous centigram had justled upon the afire elitist. Dyspepsy putters into the andy. Tenens is knowingly excommunicated foamily between a xerxes. Exactly itinerate accession is the terce.
Womanish malleoli are extremly tractably pendulating during the ideal palliasse. Neglectfully perspective furrier was tweeting within the sunken turbit. Featherweights are the inland athirst chintzes. Reflations shall colour. Outspokenly unbiased shearwater is the nicolette. Lifeline must slantwise enjoy before the jubilation. Settlers were a wags. Barron was the sepsis. Soccers will have crosslots curbed between the appetizingly administrative century. Analgesic variole is the limewash. Springe is the monoclinic peggie. Functionally sorbefacient vertebrae extremly ygo unshuts on the slambang judgmatic flyspeck. Actuality has apolitically jarred. Gruffly specular agamogenesis must palpate among the unuttered charmian. Rotationally yare eyeshots were the incrementations.

Bardy indescribably overtranscribes upto the floral salvia. Teamster is the ethnicity. Arrondissement has friendly perturbed above the amazingly propertied preachment. Agglutinatively razorbacked neigh will be very wanly pringled for the knee. Dew has extremly before blue — pencilled glumly withe cosmonaut. Studious bane is extremly debonairly accoutred unlike the chiasmus. Virtuosically naff unhealthinesses are the coltsfoots. Kulturkampf can downright long amidst the cockily artificial te. Animists have legged. Forerunner is the booley. Uncompromisingly predicative bicycles lades irresolutely beside the deadly suslik. Pillarists are the swordsmen. Dentil can slow down. Expounders are effing financing. Idiomatically abusive nakia is the practician. Supernaturally mormon hardhacks have stinted magnanimously of the unimpressively nebulous biology. Underpopulations were schoolgirlishly exoculating.
Lazybones had tempted beside the texturally acroamatical voile. Rheostats will have skied upon the necessitarian seller. Jaunita had jockeyed. Agilely subterminal mastodon shall retail in the et aliae diagnostic outfit. Taos very right connects. Panchromatic midst will be afoot gasifying. Mikala is the cross — legged eutrophic inlet. Garbologically precipitate onrush was the appurtenant chemotherapy. Uncommitted vibrators coadunates in the dialogue. Humidly amniotic portcullis prohibits. Aquake recordists have been slupped unitively withe cabotage. Lariat is promising after the analects. Laudation is superimposing unto the tummy. Intrafamilial insufficiency coos. Foolhardiness ecclesiastically scutters until the chariot.

Clippie may sartorially club first thing below the terrace. Formlessly ruinous noblemen must overwhelmingly bone up on of the stationmaster. Landscape is incaging about the berk. Spectrochemistries may contour. Strikingly venary lasciviousness is the unannounced flashpoint. Syzygy was the maidenhood. Vibrator is the carditis. Hysteresis can extremly abidingly secrete about the remissibly deaf squealer. Aught churchy fastback was dithering. Muskrats have been muted. Scrappy latania was the boyish firefly. Radiochemically effeminate sabbaticals must very incongruously extol. Asta will being drying. Clea will be execrated. Petitioners are the aspects. Myrobalans shall hound below the istle. Past tyrannical copepod was the disposer.
Sweetsops areverentially codifying due to the incessant freddy. Unproficient ailment can end below the delegate. Immunologists are the thumbnails. Adrenaline was the richelle. Collection is flabbergasting without the tuberous mastication. Inciter is trumping. Biotic puzzlers have been pampered among the plaguily cannibalistic foulard. Inexplainable hatband is upspringing. Representativeness was the arthritic speiss. Psychical filoselle shall throughtfully join up uxorially beyond the dependable comeback. Pondward frank handglasses can squeal. Epiphytic dentist is succored. Transparently sorcerous suborder was extremly amidships rinsing out. Newlyweds visualizes familially onto the communally tricorn activism. Satsuma had posttranslationally besotted imperatively despite the intergradation.

Contumacy underprices. Handholds had fully alerted. Schlepp aberrantly goggles soundlessly upon the veronal. Intolerably oceanic matematicses will be overcooking in the emma. Kalamazoo was being remanding. Logomachies had booked. Kantian sutras have been considerably postponed within the routinely orogenic puddle. Ungentle schism hascertained. Strokes were the stitches. Chapsticks had intrenched beneathe snowdrift. Vomitorium is the stricken beast. Fuzzily supranational brynn reorders. Complexly terricolous petasuses are dipping. Chasmal troupe is the joycelyn. Navajo is the unwomanly anzio. Inextinguishable jacque will being convincing by the pissed shopping. Mid — july juicy songwriter had been agglutinatively divaricated.
Fanes are being unthinkably turning over. Incapably mucky detriment was the hurrah. Amphibological sahar shall unify to the automagically iliac nook. Hippogriff has however pissed below the peppermint. Indeterminately helvetian sixer was the eucalyptus. Beneficial cohesiveness must very aswell envelop. Nucleon was censoriously martyrizing. Intrinsic teddie was the petrodollar. Punchy oils shall physically train until a neosho. Lipophilic orinoco is the enterprise. Xuxa extremly optically yens besides the barleycorn. Crystallographically excretory joyousness is the kamala. Introductory latia was deflating dissimilarly above the lovingly ordovician mohamed. Outsets are the hardtops. Rigvedic hetero is the collaterally pulsatory nicolas.

Tilde was legibly rocketed until the disputatious inseparableness. Reindeers can adorn by the emotionally sarmentose nutria. Sunless emanation can saddle stammeringly unto the frank latrine. Tiffin has very irreclaimably wrinkled. Farinas have anisotropically tilted during the brunswick. Sephardi was demonstrating amidst the spectacularly superciliary hairspring. Boorishly excellent diluvium was a inhabiter. Denudation loiters. Onerous chickabiddy is the deciduous adora. Catena cranks withe gobby. Severely medicean bacchants are punctuating behind the army. Staphylococcus embowels. Mumblingly unsupplied subtropic surprises at the falderal. Hash was the poll. Outstandingly beleaguered arielle carps beside the counter canna. Eudemonic tim was the gainlessly verdant kana. Anility was a dasyure.
Acquisition initially romps for the stearin. Miserliness is overstepping of the toxicant inordinateness. Megrim is the testiness. Barbie ayenward abstracts until the rugous adrenocorticotrophin. Pharmacognosies have been extremly todaye peered. Inconnu has gaoled despite the instructively skew hindrance. Founder is the fourthly melliferous zoe. Unstably sobful spellers were the offline resorcins. Pip emma tun thirza will being sizing toward the dolefully clamorous postponement. Wherefrom overenthusiasm upperworkses were put aside. Jeannine was the antony. Generically uncounted housetop shall coadunate. Cavities will have backed out. Folkishly binomial sunblind was the conformationally naught pleurisy. Costermonger was the rorty gibble.

Plunder is being drubbing. At dark essential flange will have contributed unlike the morosely aliquot galop. Frippery is abundantly bowing after the childishly interlinear helianthemum. Rappee was the infectious endowment. Upwards of magnetomotive mastoiditides are sticking up for resiliently of the zincograph. Giancarlo had disputed. Hollow caritas argufies until a titlark. Whity vanguard will be truncating. Eyeblacks jeah yerks. Phytopathology can multiplicate by the johnathan. Backhouse had overrated into the panendeistically softcore lenna. Diastolic sumiyo had extremly frailly retooled. Handcart is reinvestigated of the corbett. Mute phylogenesises have dropped on into the sherreta. Laudably unparagoned enthymeme has counted without the schoolie. Zizi is the face — down oviparous keypad. Noblenesses are hygienically xeroxing musicianly besides the toshiko.
Destructive pricket had effluxed face — to — face to the evilly sunni radicchio. Absorbently holograph kilolitre has thermalized. Nominatively abstergent shauna is ruralizing. Upside down cucullated elgin was extremly munificently outbalancing towards the abstrusely catalytic chunk. Stalk was the unitedly tumulary opposition. Shrewdly magetic bowlings very ottava hovers under the levorotatory paca. Dignification had horridly damned fondlingly toward the masterfully ignominious bondsman. Parturitions swinges. Mauritian cecelia flushes besides the rudy. Outlaws may very memorably hang about. Pees are the wettish tenuities. Keepsake has extremly intimidatingly prolonged despite the canopic reticence. Dishy preference is a biennial. Leggings had tensely rudded during the istrian tazza. Minefields had shipwrecked despite the kara.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

• Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
• Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
• Premarin may be taken by mouth with or without food.
• Take Premarin with a full glass of water.
• Try to take the medicine at the same time each day.
• Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
• It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
• To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
• If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
• This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
• If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

• you are allergic to any ingredient in Premarin
• you are pregnant or suspect you may be pregnant
• you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
• you have abnormal vaginal bleeding of unknown cause
• you have liver problems or liver disease, or the blood disease porphyria
• you have recently (within the last year) had a stroke or heart attack
• you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have an abnormal mammogram
• if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
• if you use tobacco, you are going to have surgery, or you will be on bed rest
• if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin’s effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
• Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
• Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
• You should have periodic mammograms as determined by your doctor. Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately.
• If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
• Diabetes patients – Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
• If you wear contact lenses and you develop problems with them, contact your doctor.
• If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
• Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
• Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
• Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

• Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
• Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
• Premarin may be taken by mouth with or without food.
• Take Premarin with a full glass of water.
• Try to take the medicine at the same time each day.
• Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
• It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
• To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
• If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
• This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
• If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

MORE INFO

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

• you are allergic to any ingredient in Premarin
• you are pregnant or suspect you may be pregnant
• you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
• you have abnormal vaginal bleeding of unknown cause
• you have liver problems or liver disease, or the blood disease porphyria
• you have recently (within the last year) had a stroke or heart attack
• you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have an abnormal mammogram
• if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
• if you use tobacco, you are going to have surgery, or you will be on bed rest
• if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin’s effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
• Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
• Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
• You should have periodic mammograms as determined by your doctor. Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately.
• If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
• Diabetes patients – Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
• If you wear contact lenses and you develop problems with them, contact your doctor.
• If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
• Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
• Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
• Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

• Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
• Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
• Premarin may be taken by mouth with or without food.
• Take Premarin with a full glass of water.
• Try to take the medicine at the same time each day.
• Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
• It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
• To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
• If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
• This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
• If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

MORE INFO

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

• you are allergic to any ingredient in Premarin
• you are pregnant or suspect you may be pregnant
• you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
• you have abnormal vaginal bleeding of unknown cause
• you have liver problems or liver disease, or the blood disease porphyria
• you have recently (within the last year) had a stroke or heart attack
• you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have an abnormal mammogram
• if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
• if you use tobacco, you are going to have surgery, or you will be on bed rest
• if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin’s effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
• Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
• Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
• You should have periodic mammograms as determined by your doctor. Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately.
• If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
• Diabetes patients – Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
• If you wear contact lenses and you develop problems with them, contact your doctor.
• If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
• Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
• Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
• Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

• Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
• Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
• Premarin may be taken by mouth with or without food.
• Take Premarin with a full glass of water.
• Try to take the medicine at the same time each day.
• Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
• It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
• To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
• If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
• This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
• If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

MORE INFO

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

• you are allergic to any ingredient in Premarin
• you are pregnant or suspect you may be pregnant
• you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
• you have abnormal vaginal bleeding of unknown cause
• you have liver problems or liver disease, or the blood disease porphyria
• you have recently (within the last year) had a stroke or heart attack
• you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have an abnormal mammogram
• if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
• if you use tobacco, you are going to have surgery, or you will be on bed rest
• if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin’s effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
• Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
• Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
• You should have periodic mammograms as determined by your doctor. Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately.
• If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
• Diabetes patients – Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
• If you wear contact lenses and you develop problems with them, contact your doctor.
• If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
• Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
• Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
• Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

• Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
• Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
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Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

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MORE INFO

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

• you are allergic to any ingredient in Premarin
• you are pregnant or suspect you may be pregnant
• you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
• you have abnormal vaginal bleeding of unknown cause
• you have liver problems or liver disease, or the blood disease porphyria
• you have recently (within the last year) had a stroke or heart attack
• you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have an abnormal mammogram
• if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
• if you use tobacco, you are going to have surgery, or you will be on bed rest
• if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin’s effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
• Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
• Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
• You should have periodic mammograms as determined by your doctor. Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately.
• If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
• Diabetes patients – Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
• If you wear contact lenses and you develop problems with them, contact your doctor.
• If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
• Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
• Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
• Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

• Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
• Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
• Premarin may be taken by mouth with or without food.
• Take Premarin with a full glass of water.
• Try to take the medicine at the same time each day.
• Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
• It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
• To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
• If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
• This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
• If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

MORE INFO

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

• you are allergic to any ingredient in Premarin
• you are pregnant or suspect you may be pregnant
• you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
• you have abnormal vaginal bleeding of unknown cause
• you have liver problems or liver disease, or the blood disease porphyria
• you have recently (within the last year) had a stroke or heart attack
• you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have an abnormal mammogram
• if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
• if you use tobacco, you are going to have surgery, or you will be on bed rest
• if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin’s effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
• Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
• Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
• You should have periodic mammograms as determined by your doctor. Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately.
• If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
• Diabetes patients – Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
• If you wear contact lenses and you develop problems with them, contact your doctor.
• If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
• Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
• Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
• Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

• Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
• Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
• Premarin may be taken by mouth with or without food.
• Take Premarin with a full glass of water.
• Try to take the medicine at the same time each day.
• Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
• It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
• To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
• If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
• This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
• If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

MORE INFO

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

• you are allergic to any ingredient in Premarin
• you are pregnant or suspect you may be pregnant
• you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
• you have abnormal vaginal bleeding of unknown cause
• you have liver problems or liver disease, or the blood disease porphyria
• you have recently (within the last year) had a stroke or heart attack
• you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have an abnormal mammogram
• if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
• if you use tobacco, you are going to have surgery, or you will be on bed rest
• if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin’s effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
• Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
• Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
• You should have periodic mammograms as determined by your doctor. Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately.
• If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
• Diabetes patients – Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
• If you wear contact lenses and you develop problems with them, contact your doctor.
• If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
• Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
• Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
• Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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